This important paper recently published in the journal Diabetologia extensively highlights the central role of lifestyle-induced chronic inflammation in the development of type 2 diabetes. The authors share data revealing that people at risk for type 2 diabetes are those for whom the inflammatory responses to those factors are more pronounced and prolonged. They state: “Chronic low-grade inflammation will eventually lead to overt diabetes if counter-regulatory circuits to inflammation and metabolic stress are compromised because of a genetic and/or epigenetic predisposition. Hence, it is not the lifestyle change per se but a deficient counter-regulatory response in predisposed individuals which is crucial to disease pathogenesis.” Everywhere you turn you will see the importance of evaluating and treating tendencies to chronic inflammation—which may be symptomatic or silent.