Posts Tagged ‘stroke’

Don’t rely on aspirin for cardiovascular protection

Friday, March 19th, 2010

JAMA 030310There’s another study just published in the Journal of the American Medical Association (JAMA) providing evidence that aspirin does not prevent a heart attack or stroke in the general population. The authors selected 3350 higher risk adults adults from a pool of 28,900 men and women by choosing those with a low ankle brachial index (ankle/arm pressure pressure ratio):

“A low ankle brachial index (ABI) indicates atherosclerosis and an increased risk of cardiovascular and cerebrovascular events. Screening for a low ABI can identify an asymptomatic higher risk group potentially amenable to preventive treatments.”

According to their study design they gave once daily 100 mg aspirin (enteric coated) or placebo…

“To determine the effectiveness of aspirin in preventing events in people with a low ABI identified on screening the general population.”

After analyzing all the data collected over a 10 year study period, this is their conclusion:

“Among participants without clinical cardiovascular disease, identified with a low ABI based on screening a general population, the administration of aspirin compared with placebo did not result in a significant reduction in vascular events.”

However, there are evidence-based interventions free of side-effects associated aspirin (GI bleeding) that have been demonstrated to reduce risk factors. These can be applied on an individual basis with the functional medicine approach that uses science and technology to objectively identify personal vulnerability and need.

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Antidepressants associated with strokes in women

Tuesday, December 15th, 2009

Here we have another good reason to use the body-friendly method of providing native precursors and cofactors to naturally increase neurotransmitters instead of using re-uptake inhibitors. This study just published in the Archives of Internal Medicine found that “Selective serotonin reuptake inhibitor (SSRI) use was associated with increased stroke risk and all-cause mortality…SSRI use was associated with incident hemorrhagic stroke and fatal stroke.” Important: there IS another way, without side effects or hazards, to improve neurotransmitter levels. Contact us for more information.

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Lp-PLA2 is a strong independent predictor of heart attack and stroke

Tuesday, December 1st, 2009

It seems that too few people (and their doctors) are aware of the value of lipoprotein-associated phospholipase A2 (Lp-PLA2) for heart attack and stroke prevention. The fact that these unfortunate events are precipitated when ‘vulnerable plaque’ breaks loose from an inflamed lesion in a blood vessel wall makes this marker of special importance—it is directly linked to those inflamed lesions. An authoritative paper published in The New England Journal of Medicine concludes:

“Inflammatory markers are predictors of the risk of coronary events….Elevated levels of lipoprotein-associated phospholipase A2 appear to be a strong risk factor for coronary heart disease, a finding that has implications for atherogenesis and the assessment of risk.”

Here are a few more reports (among numerous studies) from these journals:

  1. The Journal of Clinical Endocrinology & Metabolism
  2. Cardiology In Review
  3. Stroke [This one also links Lp-PLA2 to lesions in the brain.]
  4. European Heart Journal
  5. Arteriosclerosis, Thrombosis, and Vascular Biology
  6. Mayo Clinic Proceedings
  7. Current Opinion in Lipidology
  8. European Heart Journal (2)
  9. Cardiology in Review

I consider Lp-PLA2 a scientifically validated and important screening tool for my patients whose family history or other risk factors for cardiovascular disease are significant. See a brief video illustrating the mechanism of action.

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Migraine and strokes in women

Monday, November 30th, 2009

Ladies, if you suffer from migraine here is more inspiration for finding a sound solution. As this recent paper published in The Journal of the American Medical Association reports, migraine attacks can be associated with pathological changes in the brain. The association held true only for migraines with aura, and only for women. The authors conclude: “Migraine with aura in midlife was associated with late-life prevalence of cerebellar infarct-like lesions on MRI [infarct = death of tissue due to interruption of blood flow]. This association was statistically significant only for women. This is consistent with the hypothesis that migraine with aura in midlife is associated with late-life vascular disease in the cerebellum and in women.”

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