It’s a ‘no-brainer, of course, that ‘ecstasy’ (MDMA) would ‘burn’ the brain. This paper published in the Journal of Psychopharmacology describes research that documents what you might expect:

“…on immediate word recall and delayed word recall, both groups of MDMA users recalled significantly less words than controls. Animal research has shown that MDMA can lead to serotonergic neurodegeneration, particularly in the hippocampus and frontal cortex…these data are consistent with other findings of memory decrements in recreational MDMA users, possibly caused by serotonergic neurotoxicity.”