You are probably aware of earlier studies that demonstrated increase in life span of experimental animals by the effect of caloric restriction on insulin regulating pathways. This interesting study recently published in the journal Cell Metabolism elucidates the flip side: “We found that adding a small amount of glucose to the medium (2%) shortened the life span of C. elegans by inhibiting the activities of life span-extending transcription factors that are also inhibited by insulin signaling…” The authors conclude: “Together, these findings raise the possibility that a low-sugar diet might have beneficial effects on life span in higher organisms.”

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