Trans-palmitoleate, a good fat in dairy products

Original research published recently in the Annals of Internal Medicine offers evidence that trans-palmitoleate, a fat present in milk, is responsible for metabolic benefits observed with dairy consumption. The authors set out to…

“…To investigate whether circulating trans-palmitoleate is independently related to lower metabolic risk and incident type 2 diabetes.”

They examined 3736 adults in the Cardiovascular Health Study for plasma phospholipid fatty acids, blood lipids, inflammatory markers, and glucose–insulin and dietary habits, taking into consideration relevant demographic, clinical, and lifestyle factors. They then determined how trans-palmitoleate related to major metabolic risk factors. Their data tell an interesting story of a helpful fat:

“In multivariate analyses, whole-fat dairy consumption was most strongly associated with higher trans-palmitoleate levels. Higher trans-palmitoleate levels were associated with slightly lower adiposity and, independently, with higher high-density lipoprotein cholesterol levels, lower triglyceride levels, a lower total cholesterol–HDL cholesterol ratio, lower C-reactive protein levels, and lower insulin resistance. Trans-palmitoleate was also associated with a substantially lower incidence of diabetes…Protective associations with metabolic risk factors were confirmed in the validation cohort.”

Of course, this study does address the widespread problem of dairy allergy, nor does it discriminate between the widely varying qualities of dairy (organic from grass-fed free-range animals versus industrial dairy). But it does caution against the wholesale discrimination against fats in general and the dairy food group in particular. As always, clinical and lifestyle decisions depend on the needs of the individual which can be verified by objective outcome markers. Practitioners and health conscious individuals can consider the authors’ conclusion:

“Circulating trans-palmitoleate is associated with lower insulin resistance, presence of atherogenic dyslipidemia, and incident diabetes. Our findings may explain previously observed metabolic benefits of dairy consumption and support the need for detailed further experimental and clinical investigation.”

Even modest visceral fat gain causes blood vessel dysfunction

An interesting study just published in the Journal of the American College of Cardiology offers evidence that even a modest amount of fat around your waist prevents blood vessels from dilating properly. But there is good news too. The authors refer to endothelial function (the endothelium is the inner lining of the blood vessel; it regulates constriction and dilation):

“The aim of this study was to determine the impact of fat gain and its distribution on endothelial function in lean healthy humans…Endothelial dysfunction has been identified as an independent predictor of cardiovascular events.”

Study subjects were assigned to either gain weight or maintain the same weight while a number of functional indicators were tracked along with body composition. The metric for endothelial function was brachial artery flow-mediated dilation [FMD]. The weight gainers then lost the added weight for the final measurements. What did the data show? First the bad news, then the good:

FMD decreased in fat gainers but recovered to baseline when subjects shed the gained weight.

Subcutaneous fat gain did not degrade endothelial function. The authors sum up their findings by concluding:

“In normal-weight healthy young subjects, modest fat gain results in impaired endothelial function, even in the absence of changes in blood pressure. Endothelial function recovers after weight loss. Increased visceral rather than subcutaneous fat predicts endothelial dysfunction.”

So ‘it’s not over until the fat lady loses the weight around her waist.’

Full-fat dairy reduces cardiovascular disease?

European Journal of Clinical Nutrition 0310Studies examining the epidemiological effect of a food rarely disclose its quality and source. Do you ever wonder if a study on meat, for example, might give different results if the subjects consumed only organic grass-fed meat rather than meat from hormone and antibiotic-laced feedlot animals fed on grain silage and offal? A study recently published in the European Journal of Clinical Nutrition came up with a surprise when it investigated the effect of full-fat dairy on cardiovascular disease in Australian adults.

“Dairy foods contain various nutrients that may affect health. We investigated whether intake of dairy products or related nutrients is associated with mortality due to cardiovascular disease (CVD), cancer and all causes.”

The authors studied 1529 adult Australians over 16 years, correlating habitual intakes of dairy products with mortality and cause of death. When the numbers were analyzed an unexpected finding emerged:

“…compared with those with the lowest intake of full-fat dairy, participants with the highest intake had reduced death due to CVD after adjustment for calcium intake and other confounders.”

The data compelled them to record conclusions contrary to popular dogma:

Overall intake of dairy products was not associated with mortality. A possible beneficial association between intake of full-fat dairy and cardiovascular mortality needs further assessment and confirmation.”

Veterinary Research CommunicationsPerhaps it has something to with what the cows were eating. A study published just last month in the journal Veterinary Research Communications compared the effect of grass hay versus grain (maize = corn) on the properties of the milk to promote cardiovascular disease.

“14 Holstein dairy cows were fed…either grass hay (GH) or maize silage (MS). Milk samples were collected…and fatty acid (FA) profiles were analyzed…Milk from animals fed the GH-diet contained lower concentrations of saturated FAs and higher levels of polyunsaturated FAs (PUFAs). Feeding additional hay also increased conjugated linoleic acid and n-3 FA levels and decreased C16:0 levels.”

What do these differences in fatty acids mean for cardiovascular disease risk?

“Increases in both PUFAs and n-3 FAs resulted in lower atherogenic and thrombogenic indices in milk from animals fed the GH diet compared with those fed the MS diet. A complete substitution of GH for MS appeared to improve milk FA profiles….”

American Journal of Clinical NutritionToo bad the authors of the Australian study weren’t able to specify what those Australian cows ate. But another fascinating study just published in the American Journal of Clinical Nutrition sheds more light on the matter. The authors begin by observing:

“Despite the high saturated fat content of dairy products, no clear association between dairy product intake and risk of myocardial infarction (MI) has been observed. Dairy products are the main source of conjugated linoleic acid (CLA; 18:2n–7t), which is produced by the ruminal biohydrogenation of grasses eaten by cows. Pasture-grazing dairy cows have more CLA in their milk than do grain-fed cows. Some animal models have reported beneficial effects of CLA on atherosclerosis.”

The authors wanted to determine the association between CLA in adipose tissue and risk of MI [myocardial infarction]. They used 1813 individuals with non-fatal heart attacks compared to matched controls, in Costa Rica where people use traditional pasture-grazing for dairy cows. What did their data show?

Adipose tissue CLA was associated with a lower risk of MIDairy intake was not associated with risk of MI, despite a strong risk associated with saturated fat intake.”

Both are good for weight loss, which is better for high blood pressure: higher protein or higher fat?

European Journal of Clinical Nutrition 0310Most of you reading this are aware that a lower glycemic diet can promote weight and fat loss through its beneficial effect on insulin levels. But which is better for blood pressure control, a higher or lower protein to fat ratio? This study recently published in the European Journal of Clinical Nutrition was designed to answer that question.

“There is controversy over dietary protein’s effects on cardiovascular disease risk factors in diabetic subjects. It is unclear whether observed effects are due to increased protein or reduced carbohydrate content of the consumed diets. The aim of this study was to compare the effects of two diets differing in protein to fat ratios on cardiovascular disease risk factors.”

What did their data show? Interestingly,…

“Both diets were equally effective in promoting weight loss and fat loss and in improving fasting glycemic control, total cholesterol and low-density lipoprotein (LDL) cholesterol, but the…HP–LF [high protein-low fat] diet improved significantly both systolic and diastolic blood pressure when compared with the LP–HF [low protein-high fat] diet. No differences were observed in postprandial glucose and insulin responses.”

The authors conclude:

“A protein to fat ratio of 1.5 in diets significantly improves blood pressure and TG [triglyceride] concentrations in obese individuals with DM2 [type 2 diabetes].”

Krill oil beats fish oil for reducing fat in heart and liver

This study compared the effects of fish oil versus krill oil, with a control diet of oleic, linoleic plus alpha-linoleic oils. Fish and krill oils both lowered liver fat and inflammation compared to the control diet, 38% and 60% respectively. Krill oil, however, reduced heart triglycerides by 42% compared to the fish oil reduction of 2%. This substantial reduction of unhealthy fat deposition and inflammatory response is particular value in metabolic syndrome and type 2 diabetes.