Posts Tagged ‘erectile dysfunction’

Bicycle riding and erectile dysfunction

Saturday, July 24th, 2010

The standard bicycle seat can deliver a significant insult to the nerve and blood vessel supply to the male genitalia. There have been numerous studies investigating the relationship between bicycle riding and erectile dysfunction. The authors of a paper published a while back in The Journal of Sexual Medicine that reviewed the science set out to:

“…summarize accumulating data on the safety of bicycle riding based on medical evidence categorized by levels of evidence, including case reports, observational studies, case control studies, mechanistic studies, and population-based epidemiologic investigations. The secondary aim was to address the concerns of bicyclists and propose measures to minimize the risk of ED associated with bicycle riding.”

The mass of data revealed a clear picture and yielded specific recommendations:

Bicycle riding more than 3 hours per week was an independent relative risk for moderate to severe ED. Therefore, bicycle riders should take precautionary measures to minimize the risk of ED associated with bicycle riding: change the bicycle saddle with a protruding nose to a noseless seat, change the posture to a more upright/reclining position, change the material of the saddle (GEL), and tilt the saddle/seat downwards.”

The authors note in their conclusion:

“Straddling bicycle saddles with a nose extension is associated with suprasystolic perineal compression pressures, temporarily occluding penile perfusion and potentially inducing endothelial injury and vasculogenic ED.”

In a subsequent paper published in the same journal this year the authors revisit the problem and begin by noting:

“For many years, reports in the literature have implicated bicycle riding as causing increased risk of erectile dysfunction (ED). Perineal compression during cycling has been associated with the development of sexual complications.”

They conducted a comprehensive review of the scientific literature and found that further studies had firmly established the risk of cycling-related sexual dysfunction and extended it to females:

“There is a significant relationship between cycling-induced perineal compression leading to vascular, endothelial, and neurogenic dysfunction in men and the development of ED. Research on female bicyclists is very limited but indicates the same impairment as in male bicyclists.”

The authors of a review published earlier in European Urology caution practitioners to be aware of this widespread phenomenon. They report that a range of problems have been documented:

“The most common bicycling associated urogenital problems are nerve entrapment syndromes presenting as genitalia numbness, which is reported in 50–91% of the cyclists, followed by erectile dysfunction reported in 13–24%. Other less common symptoms include priapism, penile thrombosis, infertility, hematuria, torsion of spermatic cord, prostatitis, perineal nodular induration and elevated serum PSA, which are reported only sporadically.”

They conclude by exhorting practitioners to be alert:

“Urologists should be aware that bicycling is a potential and not an infrequent cause of a variety of urological and andrological disorders caused by overuse injuries affecting the genitourinary system.”

Perhaps this could contribute, at least to some degree, occurrences of ‘cyclist road rage’. Are there any remedies or recommendations for cyclists to follow? Another study in The Journal of Sexual Medicine investigated the condition in police officers:

“The average bicycle police officer spends 24 hours a week on his bicycle and previous studies have shown riding a bicycle with a traditional (nosed) saddle has been associated with urogenital paresthesia and sexual dysfunction.”

The officers manifested the typical problems, but also demonstrated some improvement when using a ‘no-nose saddle’:

“(i) With few exceptions, bicycle police officers were able to effectively use no-nose saddles in their police work. (ii) Use of no-nose saddles reduced most perineal pressure. (iii) Penile health improved after 6 month using no-nose saddles as measured by biothesiometry and IIEF. There was no improvement in Rigiscan® [nocturnal erection] measure after 6 months of using no nose saddles, suggesting that a longer recovery time may be needed.”

It only makes anatomical sense that insult to the nerves and blood vessels that supply the genitalia could cause sexual dysfunction in both males and females.

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Eat a Mediterranean diet for better sex

Saturday, May 22nd, 2010

Journal of Sexual MedicineTwo papers recently published in the Journal of Sexual Medicine document the benefit of the low glycemic Mediterranean diet for sexual function in both women and men. The authors of Adherence to Mediterranean Diet and Sexual Function in Women with Type 2 Diabetes evaluated how well they stuck to the diet and correlated it with sexual function…

“The Female Sexual Function Index (FSFI) was used for assessing the key dimensions of female sexual function.”

What did the data show?

“Diabetic women with the highest scores (of adherence to the diet) had lower BMI, waist circumference, and waist-to-hip ratio, a lower prevalence of depression, obesity and metabolic syndrome, a higher level of physical activity, and better glucose and lipid profiles…The proportion of sexually active women showed a significant increase…of adherence to Mediterranean dietwomen with the highest score of adherence had a lower prevalence of sexual dysfunction…These associations remained significant after adjustment for many potential confounders.”

The authors of Adherence to Mediterranean Diet and Erectile Dysfunction in Men with Type 2 Diabetes conducted a similar investigation for men. This time the International Index of Erectile Function-5 was used as a metric for sexual function. Here’s what the data showed:

“The proportion of sexually active men showed a significant increase…of adherence to Mediterranean diet. Moreover, men with the highest score of adherence were more likely to have a lower prevalence of global ED and severe ED as compared with low adherers.”

No surprise, right? Low glycemic vegetables and fruits, lots of olive oil, nuts, a little wine, etc: the Mediterranean Diet.

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Diet induced weight loss can rapidly improve sexual function for men

Monday, May 3rd, 2010

International Journal of ObesityReaders of these posts know about the profound impact of insulin resistance on glandular and metabolic function; as the authors of this study just published in the International Journal of Obesity note…

Abdominal obesity and type 2 diabetes mellitus are associated with erectile and urinary dysfunction in men.”

The investigators set out to determine the extent to which weight loss would impact overall sexual function and lower urinary tract symptoms by measuring the effects of an 8 week low-calorie diet using meal replacements* on insulin sensitivity, testosterone, erectile function, sexual desire, prostate symptoms, abdominal obesity and waist circumference. What did their data show?

“Weight loss of ~10% was significantly associated with increased insulin sensitivity, plasma testosterone levels, IIEF-5 (erectile function) and SDI (sexual desire) scores, as well as reduced WC (waist circumference) and IPSS (prostate) scores, in diabetic as well as nondiabetic men.”

They further observed that…

“The degree of weight loss was significantly associated with improvements in plasma testosterone levels, erectile function and LUTS. Reduction in LUTS was significantly associated with increased plasma testosterone, erectile function and sexual desire.”

Hence their clear-cut conclusion:

Diet-induced weight loss significantly and rapidly improves sexual function, and reduces LUTS, in obese middle-aged men with or without diabetes.”

This is a compelling illustration of the link between insulin resistance and male sexual function.

* Although effective in this study (at 800 calories per day) there are better meal replacement products available for weight loss than this one loaded with fructose, milk protein, and low grade minerals and fish oil.

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Low testosterone is associated with abdominal aneurysm

Thursday, March 25th, 2010

Journal of Clinical Endocrinology & MetabolismHere’s one more paper for now in the ‘series’ on erectile dysfunction, testosterone, cardiovascular disease and insulin resistance, this one published recently in the Journal of Clinical Endocrinology & Metabolism.

“The objective of the study was to examine whether male sex hormones are independently associated with AAA or increased abdominal aortic diameter.”

AAA (abdominal aortic aneurysm) is a swelling of the aorta in the abdomen; a rupture means sudden death. They measured abdominal aortic diameter, total testosterone, SHBG (sex hormone binding globulin), and LH (luteinizing hormone). Free testosterone was calculated. This is what they found:

Lower free testosterone and higher LH levels are independently associated with AAA in older men. Impaired gonadal function may be involved in arterial dilatation as well as occlusive vascular disease in older men.”

Add the previous two posts to this and connect the dots. Low testosterone, erectile dysfunction with cardiovascular disease, death from cardiovascular disease, aortic aneurysm (blood vessel damage), and insulin resistance are all connected. So what do you do?

Obviously life style factors and individually determined supplementation for healthy blood sugar and insulin are important. What about testosterone? Standard testosterone supplementation suppresses endogenous production after a brief ‘honeymoon’ period. This is why in my practice I always measure both free (biologically active) testosterone and free LH when evaluating male hormone function. (LH is produced by the pituitary gland. In men it stimulates the testicles to produce testosterone. When they are not responding adequately LH goes up, indicating that the problem is ‘hypogonadia‘, usually due to background inflammation. Supplementary testosterone suppresses LH and dulls the receptors over time. There is a better way….

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Erectile dysfunction predicts death with CVD

Tuesday, March 23rd, 2010

CirculationA study just published in the journal Circulation reports a result that is not too surprisingly if we consider the underlying biology of erectile dysfunction. The authors begin with this in mind:

“Although erectile dysfunction (ED) is associated with cardiovascular risk factors and atherosclerosis, it is not known whether the presence of ED is predictive of future events in individuals with cardiovascular disease. We evaluated whether ED is predictive of mortality and cardiovascular outcomes…”

After crunching the numbers on a study cohort of 1549 patients over more than two years, this is there clear-cut conclusion:

ED is a potent predictor of all-cause death and the composite of cardiovascular death, myocardial infarction, stroke, and heart failure in men with cardiovascular disease.”

They also noted this about the medications used in their trial, Altace and Micardis…

“The study medications did not influence the course or development of ED.”

There is a lot more to the functional approach to ED than ACE inhibitors and angiotensin receptor antagonists. See the next two posts.

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Restless Leg Syndrome and Erectile Dysfunction

Sunday, January 10th, 2010

SleepThose of you interested in how brain function is significant for virtually all aspects of health will like this study just published in the medical journal Sleep. It’s also another example of the importance of healthy dopamine signalling. The investigators note that Dopaminergic hypofunction in the central nervous system may contribute to restless legs syndrome (RLS) and erectile dysfunction (ED). We therefore examined whether men with RLS have higher prevalences of ED.” After analyzing the data on a group of 23,119 men they conclude: Men with RLS had a higher likelihood of concurrent ED, and the magnitude of the observed association was increased with a higher frequency of RLS symptoms. These results suggest that ED and RLS share common determinants.” The take home message here is that dopamine function can play a role in both Restless Leg Syndrome and Erectile Dysfunction. This can be helped with a functional medicine approach to restoring dopamine regulation.

Sleep MedicineCoincidentally, a related paper has also just been published in the journal Sleep Medicine examining the role of dopaminergic dysfunction and treatment in Restless Leg Syndrome. Here the authors conclude their observations by stating: “Since dopaminergic treatment can reverse delayed facilitation in RLS, we hypothesized that cortical plasticity related to dopaminergic systems may play a crucial role in RLS pathophysiology.”

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Erectile dysfunction and insulin resistance

Thursday, November 12th, 2009

Here is more evidence of the strong correlation between erectile dysfunction and insulin. This paper recently published in the Journal of Andrology clearly discerns  the “correlation between erectile function and IR and abdominal obesity.” [IR = insulin resistance. Waist circumference is a metric for abdominal obesity.] Moreover, “IR also appears to alter testosterone production.” Important: a careful reading of this paper also discloses what functional medicine practitioners and Lapis Light patients know: “a negative correlation [with erectile function] was shown only between BT (biologically active fraction) and abdominal obesity. (BT is also termed free-fraction testosterone, measured in our salivary profiles. Total testosterone is not a reliable indicator.)

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Metabolic syndrome affects sexual function for both men and women

Sunday, November 8th, 2009

Metabolic syndrome and it’s associated hormonal, neurological and vascular effects is a major factor affecting sexual function for women too, as described in this recent paper: “The MS is strongly correlated with erectile dysfunction, hypogonadism (predictors of future development of MS), and female sexual dysfunction.” [Note: MS = metabolic syndrome]

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Erectile dysfunction, metabolic syndrome & type 2 diabetes

Sunday, November 8th, 2009

Gentlemen, this paper published recently in the journal Urology represents one of many studies linking erectile dysfunction with the hormonal and vascular degeneration associated with insulin resistance in metabolic syndrome (earlier stage) and type 2 diabetes (more advanced). “In our study, the presence of T2DM [type 2 diabetes] was strongly associated with severe ED in patients with MS [metabolic syndrome]. We believe that components of MS should be taken into consideration in the diagnosis and treatment of ED.” If you like sex, take care of your blood sugar and insulin receptors.

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Male sexual function correlates with glycemic control

Sunday, October 25th, 2009

Not surprisingly, numerous factors involved in the regulation of blood sugar also impact male erectile function. This study documents the correlation between glycemic (blood sugar) control and increased risk for erectile dysfunction (ED) in type 2 diabetes. “We conclude that glycemic control is independently and inversely associated with ED in men with diabetes type 2.”

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