First study of evidence-based clinical practice guidelines for low back pain strongly supports chiropractic

The first study to properly evaluate current practice guidelines for the management of low back pain was recently published in The Spine Journal. The authors state:

Evidence-based clinical practice guidelines (CPGs) for the management of patients with acute mechanical low back pain (AM-LBP) have been defined on an international scale. Multicenter clinical trials have demonstrated that most AM-LBP patients do not receive CPG-based treatments. To date, the value of implementing full and exclusively CPG-based treatment remains unclear.”

They set out to…

“…determine if full CPGs-based study care (SC) results in greater improvement in functional outcomes than family physician–directed usual care (UC) in the treatment of AM-LBP.”

The authors employed a two-arm, parallel design, prospective, randomized controlled clinical trial using a blinded outcome assessment. Interventions were administered in a hospital-based spine program outpatient clinic to 92 patients aged 19 to 59 years with low back pain of 2 to 4 weeks’ duration. After assessment by a spine physician, the subjects were randomized to SC (reassurance and avoidance of passive treatments, acetaminophen, 4 weeks of lumbar CSMT [chiropractic spinal manipulative therapy], and return to work within 8 weeks), or family physician–directed UC [usual care], the components of which were recorded. The subjects were then examined for improvement from baseline in disability, bodily pain and physical functioning at 8, 16, and 24 weeks. What did the data show?

“The primary outcome, the unadjusted mean improvement in RDQ [disability] scores, was significantly greater in the SC group than in the UC group…Similarly, improvements in SF-36 PF [physical functioning] scores favored the SC group at all time points; however, these differences were not statistically significant. Improvements in SF-36 BP [bodily pain] scores were similar between groups. In repeated-measures analyses, global adjusted mean improvement was significantly greater in the SC group in terms of RDQ, nearly significantly greater in terms of SF-36 PF, but similar between groups in terms of SF-36 BP.”

This is evidence that CSMT (spinal manipulative therapy administered by chiropractors) reduces disability more than ‘usual care’. The authors conclude:

“This is the first reported randomized controlled trial comparing full CPG-based treatment, including spinal manipulative therapy administered by chiropractors, to family physician–directed UC in the treatment of patients with AM-LBP. Compared to family physician–directed UC, full CPG-based treatment including CSMT is associated with significantly greater improvement in condition-specific functioning.

Stroking whiskers prevents strokes from blocked arteries

We know from heart rate variability analysis that activating the brain with skillful peripheral sensory nervous stimulation can exert deeply beneficial effects by increasing parasympathetic nervous system function. A paper just published in PLoS One (Public Library of Science) offers striking evidence of the power of this type of intervention.

“Despite progress in reducing ischemic stroke damage, complete protection remains elusive. Here we demonstrate that, after permanent occlusion of a major cortical artery (middle cerebral artery; MCA), single whisker stimulation can induce complete protection of the adult rat cortex…”

This is an amazing demonstration. In order to protect the brain from a stroke caused by permanent blockage of a major artery there has to be a rapid reperfusion of the area deprived of blood and oxygen. The authors proved with blood flow imaging and other techniques that by stroking a single whisker (if done soon enough,…

“Animals that receive early treatment are histologically [cellular anatomy] and behaviorally equivalent to healthy controls and have normal neuronal function.”

Stroking induced sufficient opening of collateral vessels to provide an alternative arterial source, enough for reperfusion even though the middle cerebral artery was still blocked. The authors’ conclusion is a fascinating insight into the therapeutic potential of sensory based peripheral stimulation therapies (chiropractic, acupuncture, massage, etc.) to elicit profound improvements in autonomic regulatory function:

“These findings suggest that the cortex is capable of extensive blood flow reorganization and more importantly that mild sensory stimulation can provide complete protection from impending stroke given early intervention. Such non-invasive, non-pharmacological intervention has clear translational potential.”

This research is consonant with my clinical experience in using sensory based peripheral therapies as a regulating stimulus for both acute and chronic conditions.

Leg length difference promotes knee arthritis

Annals of Internal MedicineThis study just published in the journal Annals of Internal Medicine made me want to slap my forehead in amazement at how long it takes common sense clinical experience to be absorbed into the mainstream. Here’s the set-up for the investigation:

Leg-length inequality is common in the general population and may accelerate development of knee osteoarthritis.”

Their objective:

“To determine whether leg-length inequality is associated with prevalent, incident, and progressive knee osteoarthritis.”

On a personal note, I have been ‘lecturing’ patients about this, and treating with good effect based on the sound physiology, for over 25 years. There is a tremendous biomechanical stress impact that batters the joints of the lower extremity and spine with a significant difference in leg length. What conclusion did the authors’ data lead them to?

“Radiographic leg-length inequality was associated with prevalent, incident symptomatic, and progressive knee osteoarthritis. Leg-length inequality is a potentially modifiable risk factor for knee osteoarthritis.”

Caution: treating this requires knowledge and experience because a clinically significant leg length inequality usually involves a combination of anatomical difference in the leg bones plus neuromuscular compensations. I find it takes a minimum of 3 weeks to verify the correctness of a therapeutic lift when combined with treatment that assists the body in making the numerous adjustments to the leg length correction.

Does spinal manipulation do any good for chronic headache?

Spine JournalIs there any evidence that chiropractic adjustments help chronic headache? A study just published in The Spine Journal begins with the observation:

“Systematic reviews of randomized controlled trials suggest that spinal manipulative therapy (SMT) is efficacious for care of cervicogenic headache (CGH). The effect of SMT dose on outcomes has not been studied.”

Eighty patients with chronic cervicogenic (originating in the neck) headache were randomised for treatment with either spinal manipulation or massage therapy and their outcomes analyzed. What did the data show?

“There was an advantage for SMT over the control…For the higher dose patients, the advantage was greater. Patients receiving SMT were also more likely to achieve a 50% improvement in pain scale…Secondary outcomes showed similar trends favoring SMT. For SMT patients, the mean number of CGH was reduced by half.”

The conclusion:

“Clinically important differences between SMT and a control intervention were observed favoring SMT.”

Journal of Manipulative and Physiological TherapeuticsIn light of the importance of the role of cytokines such as TNF-α (tumor necrosis factor-alpha) in chronic inflammation, a case review recently published in the Journal of Manipulative and Physiological Therapeutics that documents a marked improvement associated with recovery from cervicogenic headache has a result of SMT:

“Two patients with whiplash injury and disk herniation developed CHA (cervical headache) associated with very high TNF-α levels. After manipulative therapy, these patients became symptom-free, and their TNF-α levels decreased substantially.”

The study size is only two patients, but it’s consistent with the findings of another study published in the same journal that show the connection between recovery from headache by manual therapy and improvements in Heart Rate Variability (analysis of changes in the intervals between heartbeats that reveals autonomic nervous system function) and mood:

“The purpose of this study was to investigate the immediate effects of head-neck massage on heart rate variability (HRV), mood states, and pressure pain thresholds (PPTs) in patients with chronic tension-type headache (CTTH).”

Heart Rate Variability is a powerful indicator of the functional state of the part of the nervous system that automatically “runs” the internal organs and functions. Most chronic conditions are characterized by excessive activity of the sympathetic nervous system (SNS) and deficient parasympathetic nervous system (PSNS) resources and less overall variability (more rigidity). The author’s data led to this conclusion:

“The application of a single session of manual therapy program produces an immediate increase of index HRV and a decrease in tension, anger status, and perceived pain in patients with CTTH.”

This is impressive, and duplicates my own clinical experience with treatment and HRV analysis. These findings help establish the scientific basis for why people feel so much better after their treatments.

What kind of treatment helps low back pain?

Clinical RehabilitationThis study recently published in the journal Clinical Rehabilitation compared the outcomes for three of the most common therapies:

“Objective: To compare spinal manipulation, back school and individual physiotherapy in the treatment of chronic low back pain.”

This was a randomized trial involving 210 patients with chronic, non-specific low back pain over a 12 month follow-up period. Here’s what the respective treatment plans involved:

Back school and individual physiotherapy scheduled 15 1-hour-sessions for 3 weeks. Back school included: group exercise, education/ ergonomics; individual physiotherapy: exercise, passive mobilization and soft-tissue treatment. Spinal manipulation, given according to Manual Medicine, scheduled 4 to 6 20’-sessions once-a-week.”

What did the data lead the researchers to conclude?

Spinal manipulation provided better short and long-term functional improvement, and more pain relief in the follow-up than either back school or individual physiotherapy.”

Musculoskeletal problem? Who can help?

Academic MedicineIf you have a musculoskeletal problem be sure to see a practitioner with an adequate level of training—there’s a lot more more to back, knee, shoulder and other problems than non-steroidal anti-inflammatory drugs. This commentary just published in the journal Academic Medicine makes it clear that musculoskeletal problems are outside the realm of expertise of many practitioners:

“Medical schools in the United States have continued to demonstrate deficiencies in musculoskeletal education.”

The authors advance their argument for maintaining human dissection in the anatomy curriculum while noting…

“A cross-sectional survey at Harvard in 2004 found that students lacked clinical confidence in dealing with the musculoskeletal system. In addition, only one quarter of the graduating class of medical students passed a nationally validated exam in basic musculoskeletal competency.”

On a personal note, the anatomy (human dissection) lab was one of the high points (scientifically and philosophically) of my formal schooling.