Posts Tagged ‘adiponectin’

Inflammation and insulin resistance genes are activated by surgery

Monday, June 28th, 2010

Journal of Clinical Endocrinology & MetabolismThis interesting paper recently published in the Journal of Clinical Endocrinology & Metabolism describes one of the reasons why support when undergoing a surgical procedure is so important (and links to the risks for delirium and accelerated dementia after surgery in the elderly). The authors set out to investigate the…

“…mechanisms behind postoperative insulin resistance and impaired glucose utilization…”

They shrewdly analyzed the expression of 21 target genes in abdominal adipose (fat) tissue from samples taken at the beginning and end of patients undergoing abdominal surgery. What did the data show?

“After surgery, both sc [subcutaneous] and omental adipose tissue mRNA levels of genes involved in the IL6 and nicotinamide phosphoribosyltransferase pathways were increased, whereas mRNA levels of insulin receptor substrate 1 and adiponectin were reduced. TNF pathway genes were differently regulated between sc and omental adipose tissue, and glucose transporter 4 mRNA levels were decreased only in omental adipose tissue.”

In other words, surgery elicits a shift in genetic expression that favors insulin resistance and inflammation. The authors conclude:

“The transcriptional output of pivotal inflammatory and insulin signaling pathway genes is altered after surgery…This could be of importance for the metabolic aberrations associated to postsurgical complications…”

This helps to understand why patients who are lucky enough to receive adjunctive support for the insulin and inflammatory signaling pathways and receptors recover faster and with less complications.

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Resistance exercise necessary for weight management and metabolic control

Saturday, January 23rd, 2010

Diabetes CareAerobic exercise, especially if performed in an interval fashion (see earlier posts) is very good, but don’t leave out the high-intensity resistance (“strength”) training for improving body composition which, of course, depends on metabolic control. This timely paper recently published in the journal Diabetes Care confirms that high-intensity resistance exercise does something that other forms of exercise don’t. Adiponectin is hormone critical for burning rather than storing fat; higher levels are better. The investigators found that “Adiponectin concentration increased after 12 h and remained elevated for 24 h only in the high-intensity group.” They go on to conclude: “Resistance exercise does increase REE and adiponectin in an intensity-dependent manner for as long as 48 and 24 h, respectively, in overweight elderly individuals. It appears that resistance exercise may represent an effective approach for weight management and metabolic control…” [REE = resting energy expenditure]

Arthritis Care & ResearchBy the way, if you are suffering from rheumatoid arthritis or another inflammatory disorder is it safe and effective for you to do high-intensity resistance training? According to this study published in the journal Arthritis Care & Research, the answer is yes. The investigators set out “To confirm, in a randomized controlled trial (RCT), the efficacy of high-intensity progressive resistance training (PRT) in restoring muscle mass and function in patients with rheumatoid arthritis (RA).” Their conclusion: “In an RCT, 24 weeks of PRT proved safe and effective in restoring lean mass and function in patients with RA…PRT should feature in disease management.”

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Patients with prostate cancer present lower cholesterol and higher triglycerides

Friday, January 1st, 2010

The Aging MaleThis interesting paper published recently in the medical journal The Aging Male reports a study in which the investigators evaluated “lipoprotein profile and sex hormones in patients with prostate cancer (PCa) and benign prostatic hyperplasia (BPH) and their possible associations with some inflammatory markers linked to PCa.” Not surprisingly, estrogen and androgens were higher and adiponectin (see forthcoming posts) was lower. The authors conclude: “Our most novel findings are that the patients with PCa presented lower total Chol and HDL-chol and higher TG/HDL-chol than BPH and Controls.” Once again, cholesterol was lower and triglycerides higher in the prostate cancer group. What drives up triglycerides more than anything else? Insulin resistance. One more interesting finding: “No differences were found in androgens between BPH and PCa.” This suggests that androgens (including testosterone) add bulk but the other factors are more significant for conversion to malignancy.

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Chili pepper reduces obesity-induced insulin resistance & liver fat

Sunday, November 1st, 2009

This welcome study demonstrates that capsaicin (the chemical that makes chilies hot) “lowered fasting glucose, insulin, leptin levels, and markedly reduced the impairment of glucose tolerance.” Levels of inflammatory cytokines (signalling molecules that increase inflammation) in fat and liver tissue also “decreased markedly”. Adiponectin (the hormone secreted in fat tissue that reduces body fat, type 2 diabetes, blood vessel deposits and fatty liver disease) was increased, along with other beneficial agents. “Our data suggest that dietary capsaicin may reduce obesity-induced glucose intolerance by not only suppressing inflammatory responses but also enhancing fatty acid oxidation in adipose tissue and/or liver.” So eat chili peppers to burn fat, suppress inflammation and improve glucose tolerance.

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