Archive for the ‘Good Eating’ Category

Full-fat dairy reduces cardiovascular disease?

Friday, July 23rd, 2010

European Journal of Clinical Nutrition 0310Studies examining the epidemiological effect of a food rarely disclose its quality and source. Do you ever wonder if a study on meat, for example, might give different results if the subjects consumed only organic grass-fed meat rather than meat from hormone and antibiotic-laced feedlot animals fed on grain silage and offal? A study recently published in the European Journal of Clinical Nutrition came up with a surprise when it investigated the effect of full-fat dairy on cardiovascular disease in Australian adults.

“Dairy foods contain various nutrients that may affect health. We investigated whether intake of dairy products or related nutrients is associated with mortality due to cardiovascular disease (CVD), cancer and all causes.”

The authors studied 1529 adult Australians over 16 years, correlating habitual intakes of dairy products with mortality and cause of death. When the numbers were analyzed an unexpected finding emerged:

“…compared with those with the lowest intake of full-fat dairy, participants with the highest intake had reduced death due to CVD after adjustment for calcium intake and other confounders.”

The data compelled them to record conclusions contrary to popular dogma:

Overall intake of dairy products was not associated with mortality. A possible beneficial association between intake of full-fat dairy and cardiovascular mortality needs further assessment and confirmation.”

Veterinary Research CommunicationsPerhaps it has something to with what the cows were eating. A study published just last month in the journal Veterinary Research Communications compared the effect of grass hay versus grain (maize = corn) on the properties of the milk to promote cardiovascular disease.

“14 Holstein dairy cows were fed…either grass hay (GH) or maize silage (MS). Milk samples were collected…and fatty acid (FA) profiles were analyzed…Milk from animals fed the GH-diet contained lower concentrations of saturated FAs and higher levels of polyunsaturated FAs (PUFAs). Feeding additional hay also increased conjugated linoleic acid and n-3 FA levels and decreased C16:0 levels.”

What do these differences in fatty acids mean for cardiovascular disease risk?

“Increases in both PUFAs and n-3 FAs resulted in lower atherogenic and thrombogenic indices in milk from animals fed the GH diet compared with those fed the MS diet. A complete substitution of GH for MS appeared to improve milk FA profiles….”

American Journal of Clinical NutritionToo bad the authors of the Australian study weren’t able to specify what those Australian cows ate. But another fascinating study just published in the American Journal of Clinical Nutrition sheds more light on the matter. The authors begin by observing:

“Despite the high saturated fat content of dairy products, no clear association between dairy product intake and risk of myocardial infarction (MI) has been observed. Dairy products are the main source of conjugated linoleic acid (CLA; 18:2n–7t), which is produced by the ruminal biohydrogenation of grasses eaten by cows. Pasture-grazing dairy cows have more CLA in their milk than do grain-fed cows. Some animal models have reported beneficial effects of CLA on atherosclerosis.”

The authors wanted to determine the association between CLA in adipose tissue and risk of MI [myocardial infarction]. They used 1813 individuals with non-fatal heart attacks compared to matched controls, in Costa Rica where people use traditional pasture-grazing for dairy cows. What did their data show?

Adipose tissue CLA was associated with a lower risk of MIDairy intake was not associated with risk of MI, despite a strong risk associated with saturated fat intake.”

More evidence that coffee helps blood sugar and liver inflammation

Tuesday, May 25th, 2010

Journal of Agricultural and Food ChemistryYet another study on the benefits of coffee was just published in the Journal of Agricultural and Food Chemistry. This ones demonstrates how this salubrious beverage improves insulin function and fatty liver by reducing inflammation. The authors observe:

“Epidemiological surveys have demonstrated that habitual coffee consumption reduces the risk of type 2 diabetes. The aim of this work was to study the antidiabetic effect of coffee and caffeine in spontaneously diabetic KK-Ay mice.”

The mice were not taken to Starbucks for mini espresso shots, but were…

“…given regular drinking water (controls) or 2-fold diluted coffee for 5 weeks.”

The results were pretty amazing:

“Coffee ingestion ameliorated the development of hyperglycemia and improved insulin sensitivity. White adipose tissue mRNA levels of inflammatory cytokines (MCP-1, IL-6, and TNFα), adipose tissue MCP-1 concentration, and serum IL-6 concentration in the coffee group were lower than the control group. Moreover, coffee ingestion improved the fatty liver.”

The authors summed up their findings by stating:

“…coffee exerts a suppressive effect on hyperglycemia by improving insulin sensitivity, partly due to reducing inflammatory cytokine expression and improving fatty liver. Moreover, caffeine may be one of the effective antidiabetic compounds in coffee.”

Trans fats increase risk of endometriosis

Monday, May 10th, 2010

Human ReproductionThe authors of this study published recently in the journal Human Reproduction analyzed 12 years of data from the Nurses’ Health Study II to discriminate any link between dietary fat intake and the risk of endometriosis. Their analysis revealed that…

“Although total fat consumption was not associated with endometriosis risk, those women in the highest fifth of long-chain omega-3 fatty acid consumption were 22% less likely to be diagnosed with endometriosis…In addition, those in the highest quintile of trans-unsaturated fat intake were 48% more likely to be diagnosed with endometriosis.”

Considering the other well-known deleterious effects of trans fats, their conclusion is easy to digest:

“These data suggest that specific types of dietary fat are associated with the incidence of laparoscopically confirmed endometriosis, and that these relations may indicate modifiable risk. This evidence additionally provides another disease association that supports efforts to remove trans fat from hydrogenated oils from the food supply.”

By the way, endometriosis is not always so easy to diagnose. Another paper published in the same journal documents the accuracy of a non-invasive diagnosis of endometriosis using plasma (blood) biomarkers:

“Plasma levels of IL-6, IL-8 and CA-125 were increased in all women with endometriosis and in those with minimal–mild endometriosis, compared with controls. In women with moderate–severe endometriosis, plasma levels of IL-6, IL-8 and CA-125, but also of hsCRP, were significantly higher than in controls.”

Yet again we see the diagnostic importance of cytokines (IL-6 and IL-8 in this case). The authors affirm that this method has good sensitivity and specificity:

“Using stepwise logistic regression, moderate–severe endometriosis was diagnosed with a sensitivity of 100% (specificity 84%) and minimal–mild endometriosis was detected with a sensitivity of 87% (specificity 71%) during the secretory phase.”

Action points: (1) Minimize trans fats in your diet in any case. (2) If you suspect an inflammatory disorder ask your doctor about tests for cytokines.

Do nuts really help with diabetes and cardiovascular disease?

Saturday, May 8th, 2010

British Journal of NutritionThe authors of this paper published in the British Journal of Nutrition begin by observing…

“The ability of nuts to improve the blood lipid profile and reduce the risk of CHD (coronary heart disease) is now well established. The interest that health effects of nuts have gained recently has brought the possible benefits of consuming nuts, such as improvement in the conditions of the metabolic syndrome, and their potential to prevent and control diabetes into focus.”

They report an important observation:

“Acute feeding studies indicate that nuts have minimal effects on rising postprandial blood glucose levels when eaten alone, and diminish the postprandial glycaemic response when consumed with high-glycaemic index carbohydrate foods in both normoglycaemic and type 2 diabetic individuals.”

This means that whether your blood sugar is still OK or has already gone too high, if you consume nuts with a meal or snack—even if it is, at least to a degree, more glycemic than desirable—the nuts will prevent your blood sugar from spiking too high and overstimulating the release of insulin. And eating nuts alone has a trivial effect on raising blood sugar.

The authors further note…

“Nuts have a healthy nutritional profile, high in MUFA (monounsaturated fatty acids) and PUFA (polyunsaturated fatty acids), are a good source of vegetable protein and are rich in fibre, vitamins and minerals….early data indicate that the inclusion of nuts in the diets of individuals with diabetes and the metabolic syndrome is warranted, in view of their potential to reduce CHD risk.”

However, don’t forget that tree nuts are among the more common food allergens.

Sugars raise bad fats in the blood

Tuesday, May 4th, 2010

JAMAReaders and patients here know how higher levels of insulin from a high glycemic diet can result in an increase in the harmful kinds of fat in the blood. It will come as no surprise that a paper just published in the Journal of the American Medical Association adds more evidence to the association. The the objective of the authors was to…

“…assess the association between consumption of added sugars and blood lipid levels in US adults.”

They analyzed the data for 6,113 adults collected over seven years for sugars in the diet and levels of HDL and LDL cholesterol and triglycerides. A clear correlation between higher levels of sugars and lower HDL (“good” cholesterol), higher LDL (“bad” cholesterol) and higher triglycerides emerged. There was strong evidence for maintaining a low glycemic diet to regulate cholesterol:

Among higher consumers (≥10% added sugars) the odds of low HDL-C levels were 50% to more than 300% greater compared with the reference group (<5% added sugars).”

Their conclusion was mildly stated:

“In this study, there was a statistically significant correlation between dietary added sugars and blood lipid levels among US adults.”

Journal of Lipid ResearchHave you been trying but not succeeding in getting cholesterol and/or triglycerides down with a low fat diet? There has been so much science done on the correlation between insulin sensitivity and cholesterol levels; it’s surprising this wasn’t noted by the authors. Just one example is a fresh paper in the Journal of Lipid Research that begins with the well-known fact:

“Cholesterol synthesis is upregulated and absorption downregulated in insulin resistance and in type 2 diabetes.”

Interestingly, the authors wanted to see if any level of insulin resistance would have an effect on cholesterol synthesis:

“We investigated whether alterations in cholesterol metabolism are observed across the glucose tolerance status, from normoglycemia through impaired glucose tolerance to type 2 diabetes…”

What conclusions did they draw from their data?

“In conclusion, cholesterol metabolism was altered already in subjects with impaired fasting glucose. Upregulated cholesterol synthesis was associated with peripheral insulin resistance independent of obesity.”

How to eat healthy fat and oil is another topic, but if cholesterol and triglycerides are the issue—pay attention to sugars and insulin.

Mercury levels found to be higher in restaurant sushi tuna than supermarket

Friday, April 23rd, 2010

Biology LettersAn innovative and alarming study was just published in the journal Biology Letters that not only confirms the high level of toxicity of certain tuna species and uses DNA ‘barcode’ technology to reveal that the type of tuna in most restaurant sushi is the most contaminated with mercury.

The authors remind us:

“Excessive ingestion of mercury—a health hazard associated with consuming predatory fishes—damages neurological, sensory-motor and cardiovascular functioning.”

It can be difficult to identify a specific tuna species and know where it came from using conventional methods. This is where DNA barcodes advances the science:

“Accurate identification of commercial fish species has many public health and legal applications. DNA barcodes—short nucleotide sequences used to identify species—can serve as an important tool allowing regulatory agencies to recognize ambiguous food items that are fraudulent or hazardous.”

The authors undertook an extensive study to match confirmed identity with mercury content:

“We tested the mercury content of 100 tuna sushi samples from 54 restaurants and 15 supermarkets collected from October 2007 to December 2009 in New York, New Jersey, and Colorado.”

What did they find?

The mean mercury concentrations of all samples exceed the concentration permitted by Japan, and the maximum daily consumption considered safe by the US Environmental Protection Agency. Mean mercury levels for bluefin akami exceed those permitted by the US Food and Drug Administration, Health Canada and the European Commission.On average, one order of Bigeye Tuna sushi—the species used most often for sushi—exceeds the safe maximum daily dose recommended by Health Canada and the safe limit established by the World Health Organization and FAO for women of childbearing age.”

Moreover…

“Because the mercury concentrations found in our sushi were significantly higher than levels documented by the Food and Drug Administration this could reflect that our samples came from larger fish (the FDA lacks bluefin data). We found significantly lower mercury levels in supermarket sushi because samples were dominated by Yellowfin Tuna, which comprised a minority of restaurant samples and was found to be the species with the lowest mercury concentration.”

Science NowAt this time health agencies are  not using these findings that place Bigeye and bluefin tuna in the category that the FDA and EPA advise should be totally avoided by pregnant or nursing women and children. You may also like to read a report on this study published in Science Now by the American Academy of Sciences. How do you find out if mercury is a problem for you? Not by provoked chelation (see the earlier post), and inquire about or ‘stay tuned’ for posts on porphyrin profiles, anti-mercury antibodies and MELISA test technology.

Can chili peppers help gastritis?

Sunday, April 18th, 2010

HelicobacterFirst of all, isn’t it interesting that there is so much science being done that there is a journal called Helicobacter devoted to research on the bacteria Helicobacter pylorii? Most of you will recognize it as the pathogen associated with gastric ulcers and gastritis (stomach inflammation). A study published there investigated the effect of capsaicin (the chemical that makes chilies hot) on the stomach lining when there is inflammation due to Helicobacter infection.

“Capsaicin, the main pungent ingredient of hot red and chili pepper, has been considered as not only a cytoprotective [cell protector] but also a detrimental agent to the gastric mucosa. However, the effect and mechanism of capsaicin that modulate the induction of pro-inflammatory cytokine in Helicobacter pylori-infected epithelial cells have not been investigated previously.”

The authors exposed gastric cells with various concentrations of capsaicin. Their data showed that even a very low dose of capsaicin reduced inflammation by inhibiting H. pylori-induced IL-8 and NF-κB inflammatory pathways, leading to this conclusion:

“Nontoxic dose of capsaicin inhibited H. pylori-induced IL-8 production by gastric epithelial cells through the modulation of IκB-, NF-κB-, and IL-8 pathways. We conclude that capsaicin can be proposed as a potential anti-inflammatory drug by inhibition of the production of IL-8 in H. pylori-infected gastric epithelium.”

This doesn’t mean that you don’t need to fully get rid of the Helicobacter infection. We can diagnose it much more accurately than in the past with advanced DNA amplification technology. But a little warmth in your food might help reduce the inflammation meanwhile.

Is grass-fed beef more nutritious?

Monday, March 22nd, 2010

Nutrition JournalLike us, cattle have a very different metabolic response to eating lots of green vegetables (grass in this case) versus grains. This paper recently published in the Nutrition Journal reviews research performed over the last thirty years:

“Research spanning three decades suggests that grass-based diets can significantly improve the fatty acid (FA) composition and antioxidant content of beef, albeit with variable impacts on overall palatability.”

Personally, I much prefer the taste of grass-fed beef as do others I know. They detail some of the differences:

“Grass-based diets have been shown to enhance total conjugated linoleic acid isomers…and omega-3 FAs (fatty acids)on a g/g fat basis…grass-finished beef tends toward a higher proportion of cholesterol neutral stearic FA and less cholesterol-elevating SFAs such as myristic and palmitic FAs. Several studies suggest that grass-based diets elevate precursors for Vitamin A and E, as well as cancer fighting antioxidants such as glutathione and superoxide dismutase activity as compared to grain-fed contemporaries…”

They alert consumers to the different color grass-fed beef may have due to a higher carotenoid (vitamin A precursor) content as well as different cooking characteristics.  They don’t, however, note in their paper how much more humane aBioMed Central grass-fed lifestyle is compared to grain-fed factory farming. By the way, how do you think studies on an association between red meat and various cancers might have turned out if only organic grass-fed beef was used…?

Two new studies again show benefits of coffee

Saturday, February 27th, 2010

American Journal of Clinical NutritionCoffee is in the science news again, with two interesting papers that document its benefits. Both were recently published in the American Journal of Clinical Nutrition. The first paper adds more evidence that drinking coffee reduces the risk of type 2 diabetes. The study involved 69,532 French women who were observed over an 11 year period. The authors report an “inverse association [diabetes]…for both regular and decaffeinated coffee and for filtered and black coffee, with no effect of sweetening. Total caffeine intake was also associated with a statistically significantly lower risk of diabetes. Neither tea nor chicory consumption was associated with diabetes risk.” Interestingly, the authors also noted that the observed benefit was particularly pronounced with coffee consumed at lunch. Their conclusion: “Our data support an inverse association between coffee consumption and diabetes and suggest that the time of drinking coffee plays a distinct role in glucose metabolism.”

Considering the importance of inflammation in chronic disease, the second paper is especially interesting in that it documents reductions in subclinical inflammation and oxidative stress as mechanisms by which coffee lowers the risk of type 2 diabetes. Noting that “Coffee consumption is associated with a decreased risk of type 2 diabetes,” the authors state that their “aim was to investigate the effects of daily coffee consumption on biomarkers of coffee intake, subclinical inflammation, oxidative stress, glucose, and lipid metabolism.” They observed a number of interesting effects, including beneficial lowering of the LDL/HDL ratio and IL-18, and an increase in adiponectin. Meanwhile, no adverse changes were seen on the oral glucose tolerance test. They conclude: “Coffee consumption appears to have beneficial effects on subclinical inflammation and HDL cholesterol, whereas no [adverse] changes in glucose metabolism were found in our study.”

Champagne helps open up blood vessels for heart protection

Thursday, December 31st, 2009

British Journal of NutritionIn time for New Year’s eve, an interesting study was recently published in the British Journal of Nutrition that investigated the effects of champagne on blood vessel function. “In order to assess whether acute and moderate Champagne wine consumption is capable of modulating vascular function, we performed a randomised, placebo-controlled, cross-over intervention trial.” The authors stated in their findings that “consumption of Champagne wine, but not a control matched for alcohol, carbohydrate and fruit-derived acid content, induced an acute change in endothelium-independent vasodilatation at 4 and 8 h post-consumption.” (Vasodilation = blood vessel opening.) They also observed “a significant decrease in plasma levels of oxidising species,” and conclude: “Our data suggest that a daily moderate consumption of Champagne wine may improve vascular performance…” Best wishes for the new year!